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PET-guided treatment de-escalation keeps HER2-positive breast cancer outcomes strong at five years

A five-year secondary analysis of the phase 2 PHERGain trial supports a PET-guided adaptive strategy that reduces chemotherapy in HER2-positive early breast cancer, while exploratory circulating tumor DNA findings may shape future treatment decisions.

5-year outcomes of chemotherapy de-escalation in HER2-positive early breast cancer and exploratory circulating tumor DNA analyses from the randomized phase 2 PHERGain trial
PET-guided treatment de-escalation keeps HER2-positive breast cancer outcomes strong at five years
Jenny Mealing · CC BY 2.0 · rights

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A five-year secondary analysis of the phase 2 PHERGain trial supports a PET-guided adaptive strategy that reduces chemotherapy in HER2-positive early breast cancer, while exploratory circulating tumor DNA findings may shape future treatment decisions.