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WILLOW Cohort B Analysis Questions Endpoint Design in Lupus Trials

A correspondence in The Lancet argues that the WILLOW trial's Cohort B results reveal a mismatch between the drug's biological mechanism and the composite endpoint chosen to measure it, complicating interpretation of the enpatoran dose-response data.

[Correspondence] Mechanism–endpoint matching in lupus: WILLOW Cohort B
WILLOW Cohort B Analysis Questions Endpoint Design in Lupus Trials
IAU and Sky & Telescope · CC BY 4.0 · rights

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A correspondence in The Lancet argues that the WILLOW trial's Cohort B results reveal a mismatch between the drug's biological mechanism and the composite endpoint chosen to measure it, complicating interpretation of the enpatoran dose-response data.