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Engineered tumor-infiltrating cell therapy shows early signal in melanoma resistant to checkpoint inhibitors

A pooled analysis of two early-stage trials found that amsokigene autoleucel was manufactured successfully, was well tolerated and showed a preliminary efficacy signal in patients with immune checkpoint inhibitor-refractory melanoma.

Regulatable membrane-bound IL-15 engineered TIL cell therapy for immune checkpoint inhibitor-resistant advanced melanoma: pooled analysis of phase 1 and 1/2 trials
Engineered tumor-infiltrating cell therapy shows early signal in melanoma resistant to checkpoint inhibitors
Frontiers in Oncology · CC BY 3.0 · rights

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A pooled analysis of two early-stage trials found that amsokigene autoleucel was manufactured successfully, was well tolerated and showed a preliminary efficacy signal in patients with immune checkpoint inhibitor-refractory melanoma.